We fix the root cause
of deep tech stagnation.
With a system that makes decisions scientifically predictable.
You are asked to make decisions
in a system that gives you almost no visibility.
The result is not random. It repeats everywhere.
More than 70% of scientific discovery results cannot be replicated, yet teams are pushed ahead long before the evidence is stable enough to support it.
Across Europe most deep tech ventures stall between TRL 4 and 6 as billions of grants flow in but very few ever reach industrial scale or Series B.
Incubators and accelerators optimise for activity and cohort size, which feels like progress inside but produces a graveyard of stalled prototypes.
Venture capital applies SaaS style metrics to science, creating false positives that collapse on validation and false negatives that never get funded.
Venture studios burn months chasing ideas that cannot scale in reality because they lacked a way to see the technical and economic limits early on.
Our response
The first RD&I-certified Operating System for science commercialization.
It gives you clarity on what drives progress and what drives collapse in science-driven ventures.
4x4-TETRA is not a method you try.
It is a system your organisation installs to make better decisions every single week.
What 4x4-TETRA gives you
• A clear map of what matters at each maturity point in a scientific venture.
• A way to see whether a team is moving in the right sequence or drifting into a dead zone.
• A shared language for directors, analysts, mentors and technical reviewers.
• Early warnings for collapse patterns that usually stay invisible until it is too late.
• The ability to distinguish real progress from activity that only looks like progress.
Most institutions navigate deep tech by instinct because they never had a system built for scientific ventures.
4x4-TETRA replaces instinct with measurable clarity.
About
Maria Witte, CEO
Arise Innovations
- where Science meets Commercial Strategy
& Innovation becomes Reality
Maria is the inventor of 4x4-TETRA Deep Tech Matrix™ , the first RD&I certified operating system for deep tech institutions. She has led more than 150 deep tech projects and supported over €90M in funding outcomes. 98% of her long-term clients successfully avoided the Valley of Death.
Maria has trained and advised in European programs including MassChallenge, EIT Digital & Health, INAM, HIGHEST and Life Science Factory on deep tech commercialization and evidence based decision making.
Her background in chemistry, R&D, regulatory work and venture building, enhanced on neuroscience, gives her a rare cross-disciplinary view on why scientific ventures stall and how to make their progress scientifically predictable.
